广西11选5开奖结果查询 www.odglv.com 講座編號：jz-yjsb-2019-y031
講座題目：AOP based integrated approaches to testing and assessment for skin sensitization hazard and potency
主 講 人：張全順 美國體外科學研究院教育和外聯項目科學計劃主任
張全順，資深毒理學科學家，畢業于南京農業大學，現任美國體外科學研究所（Institute for In Vitro Sciences，IIVS）教育和外聯項目科學計劃主任。張博士曾在上海出入境檢驗檢疫局從事產品毒理學檢測及臨床安全評價工作，有十年的海關檢疫工作經驗，2000年赴美在普洛威頓斯學院和塔夫茨大學從事產品安全檢測和臨床評價的研究工作，積累了豐富的化妝品產品研發，安全和功效評價經驗。張博士曾擔任塔夫茨大學的研究助理教授，積累了豐富的化妝品產品研發，安全和功效評價經驗。目前他負責的化妝品體外安全功效評價教育和外聯項目主要在中國，巴西和俄羅斯進行。
Skin sensitization is a common toxicity endpoint of concern in various industries and accounts for 10-15% of known occupational illness in the U.S. and Europe. Mechanisms of skin sensitization have been investigated intensively for many years and are documented by the Organization for Economic Co-operation and Development (OECD) in its publication, ”The Adverse Outcome Pathway for Skin Sensitization Initiated by Covalent Binding to Proteins”. The adverse outcome pathway (AOP) includes four key mechanistic events: (1) binding of hapten to endogenous proteins in the skin, (2) keratinocyte activation, (3) dendritic cell activation, and (4) proliferation of antigen-specific T cells. The most commonly used animal test, the murine local lymph node assay (LLNA) is based on the understanding of this complex series of events underlying the immune response after expose to a chemical sensitizer, and covers all key events. However, the construction of the AOP for skin sensitization has enabled the development of a multitude of non-animal test methods that are associated with one or more of the AOP key events. However, the complexity of the underlying biology indicates that no single measurement is yet sufficient to predict sensitizer potency. Therefore, it is generally assumed that only a combination of several methods in an integrated testing strategy will obviate the need for animal testing. Many testing strategies combining non-animal methods are developed with defined approaches. The defined approaches are able to either predict skin sensitization hazard (sensitizer versus non-sensitizer) or assign the test substance to one of three skin sensitization potency categories. Here we will introduce an evaluation of defined approaches (DAs) representing non-animal skin sensitization testing strategies performed by the Cosmetics Europe skin tolerance task force and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods.